Our Program
Bayer has joined forces with world-class academic institutions and other pharma companies as part of the Structural Genomics Consortium (SGC):
In an Open Science effort we identify chemical probes for novel drug discovery targets and make them openly available for academic labs who can use these probes without any restrictions to study the disease relevance of such novel targets.
This joint effort is for the benefit of patients as high-quality science forms the basis for the next generation of therapeutics. The program is also part of the European IMI project EUbeOPEN.
Your order
can be placed through
Our Offer
A set of well-characterized compounds (with corresponding negative probe). Browse the list below!
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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
ACS Chem. Biol., 12 (11): 2730-2736m
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Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60(9): 4002–4022
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Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2-d]pyrimidine based in vitro Probe BAY-885 for the Kinase ERK5.
J Med Chem. 2018 Dec 18
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manuscript submitted
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Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-576.
ChemMedChem 11(29): 2261-2271ca
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Discovery and First Structural Disclosure of an Oral GnRH Receptor Antagonist and ist Characterization in Vitro, in Animals and Humans
19th RSC / SCI Medicinal Chemistry Symposium 2017, Cambridge, UK
Olaf Panknin, Andrea Wagenfeld
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Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311
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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. J Med Chem. 2018 Mar 22;61(6):2533-2551
Donated Chemical Probes for Open Science. Elife 2018 Apr 20;7 e34311
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Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
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tbd
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Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-
Based in Vivo Probe (BAY-598)
for the Protein Lysine Methyltransferase SMYD2.
Journal of Medicinal Chemistry, 59(10): 4578-600
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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25
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Novel TIE-2 Inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models.
J Neurochem 140;170-182
Donated Chemical Probes for Open Science.
Elife 2018 Apr 20;7 e34311
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manuscript submitted
