The 3R strategy - Reduce, Refine, Replace - is of central importance for ethical and scientific standards in life science research. These principles were introduced in the 1950s by scientists William Russell and Rex Burch in their book “The Principles of Humane Experimental Technique”. They recognized the need to minimize animal experimentation while improving the quality of research. The 3Rs provide a structured approach to reducing the use of animals in research and optimizing conditions for the animals.

The importance of the 3Rs for companies like Bayer lies not only in the ethical responsibility, but also in the improvement of research results.

By applying these principles, we can reduce the number of laboratory animals required by developing more efficient experimental designs and using alternative methods. This not only helps to reduce the burden on the animals, but also improves the relevance and transferability of the results to humans.

In addition, the principle of “refine” enables us to optimize the living conditions of the animals during the experiments. By implementing improved care and handling practices, we can minimize stress and pain for the animals, leading to valid and reproducible results.

The third principle, “Replace” (avoid), encourages researchers to find alternative methods that can completely replace the use of animals, such as in vitro models or computer-based simulations. These approaches not only promote ethical research practice, but also contribute to the development of innovative technologies that ultimately increase the efficiency of research.

Overall, the 3Rs are not only an ethical obligation for Bayer, but also a strategic approach to promoting innovation and responsibility in research. By continuously implementing these principles, we can ensure that we adhere to both scientific and moral standards in life science research.